Engineering the methylotrophic yeast for lactate production from methanol.

Lactate has gained increasing attention as a platform chemical, particularly for the production of the bioplastic poly-lactic acid (PLA). While current microbial lactate production processes primarily rely on the use of sugars as carbon sources, it is possible to envision a future where lactate can be produced from sustainable, non-food substrates. Methanol could be such a potential substrate, as it can be produced by (electro)chemical hydrogenation from CO.

COVID19 Limits on Physician Shadowing Harm Undergraduate Students' Futures.

Shadowing is constantly praised as an essential component of an undergraduate student's pre-medical journey, at times even described as "ubiquitous." Whether a student decides to pursue a career as a physician or a different pathway, students report shadowing as a key deciding factor. For students considering a career in medicine, shadowing is a unique opportunity to understand physician-patient interactions.

Effect of a guideline-based multicomponent intervention on use of physical restraints in nursing homes: a randomized controlled trial.

Context: Despite unambiguous legal regulation and evidence for lack of effectiveness and safety, physical restraints are still frequently administered in nursing homes.

Objective: To reduce physical restraint prevalence in nursing homes using a guideline- and theory-based multicomponent intervention.

Design, Setting, And Participants: Cluster randomized controlled trial of 6 months' duration conducted in 2 German cities between February 2009 and April 2010.