Publications by authors named "A Hauswirth"
Article Synopsis
- Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are serious blood cancers that involve the rapid increase of abnormal white blood cells, and recent research has highlighted BRD4 and MYC as potential targets for new drug therapies.
- In experiments comparing various BRD4-targeting drugs, including the BET inhibitor JQ1 and BRD4 degraders dBET1 and dBET6, all three were effective at reducing the growth of AML and ALL cells, including resistant leukemic stem cells.
- Notably, dBET6 outperformed the others by overcoming drug resistance, showing especially promising results when paired with other medications, and it also inhibited the expression of the resistance-related PD-L1 antigen in
Article Synopsis
- * A study showed that CML patients had significantly more CD203c-positive leukocytes compared to healthy individuals, indicating a strong correlation between CD203c levels and disease risk.
- * Successful treatment with medications like imatinib led to a notable decrease in CD203c basophils, suggesting that CD203c could be used as a biomarker to monitor basophilia in CML patients throughout their treatment journey.
Patient-related factors are of prognostic importance in acute myeloid leukemia (AML). Likewise, cardiac disorders may limit the tolerance of intensive therapy. Little is known about the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP).
View Article and Find Full Text PDFWhen exposing food and feedstuff to cold atmospheric pressure plasmas (CAPP), e.g., for decontamination purposes, possible unwanted effects on the contained nutrients might occur.
View Article and Find Full Text PDFAcute lymphoblastic leukemia (ALL) is a rare hematological malignancy characterized by proliferation and accumulation of premature lymphoid blasts. Depending on risk factors, the survival of acute lymphoblastic leukemia has significantly improved over the last decades. During the last years, measurable residual disease (MRD) assessment has evolved into one of the most sensitive markers for prognosis and risk of relapse.
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