[Christmas article: collisions between roe deer and ambulances].

Introduction: Preoperative templating in hip arthroplasty surgery is crucial for accurate implant selection and reducing postoperative complications. This study examines whether there is a correlation between femoral head size and shoe size, with the aim of simplifying the preoperative planning process.

Methods: A total of 14 patients had their shoe size and femoral head size measured.

A novel plate design for rotational guided growth: An experimental study in immature porcine femurs.

Guided growth for correction of rotational deformities has been reported in several preclinical and clinical studies. Different adverse effects, like growth retardation, articular deformities, and rebound effect have been reported. We have tested a novel plate concept (RotOs Plate) intended for the correction of rotational deformities of long bones by guided growth in a porcine model.

Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease.

A major fraction of loci identified by genome-wide association studies (GWASs) mediate alternative splicing, but mechanistic interpretation is hindered by the technical limitations of short-read RNA sequencing (RNA-seq), which cannot directly link splicing events to full-length protein isoforms. Long-read RNA-seq represents a powerful tool to characterize transcript isoforms, and recently, infer protein isoform existence. Here, we present an approach that integrates information from GWASs, splicing quantitative trait loci (sQTLs), and PacBio long-read RNA-seq in a disease-relevant model to infer the effects of sQTLs on the ultimate protein isoform products they encode.

NO1 tailors its secretome for different lignocellulosic substrates.

NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate the ability of NO1 to tailor its secretome for growth on different lignocellulosic substrates. Proteomic analysis of soluble and insoluble culture fractions following the growth of NO1 on six lignocellulosic substrates highlights the adaptability of the response of the NO1 secretome to different substrates.