Evaluation of the success rate, prosthesis-related quality of life, and satisfaction in patients undergoing rehabilitation with an implant-supported auricular prosthesis.

The aim of this study was to evaluate the success rate, prosthesis-related quality of life (QoL), and satisfaction of patients undergoing rehabilitation with endosseous implants in the auricular region. This was a retrospective mixed cohort study involving 22 consecutive eligible patients (11 female, 11 male) with ear defects, treated during 1999-2019. The variables analysed were sex, age at the time of implant placement, date of last prosthesis delivery, level of education, aetiology of the deformity, and radiation history.

Comparison of the Effect of Active Video Games and Transcranial Direct Current Stimulation on Executive Functions of the Elderly: A Randomized Clinical Trial Study.

Objectives: Among the changes related to aging in the elderly, a decline in executive functions is notable. The present study aimed to investigate the comparative impact of active video games (AVG) and transcranial direct current stimulation (tDCS) on executive functions in elderly individuals in Khuzestan province, Iran.

Methods: This research employed a randomized controlled trial with a pretest-posttest design, including a control group and follow-up.

CRISPR-based gene editing in plants: Focus on reagents and their delivery tools.

Introduction: CRISPR-Cas9 technology has revolutionized plant genome editing, providing precise and efficient methods for genetic modification. This study focuses on the advancements and delivery of CRISPR-Cas9 in plant gene editing.

Methods: A comprehensive search in scientific databases, including PubMed, ScienceDirect, and Google Scholar, was conducted to gather information on CRISPR-Cas9 gene editing and its delivery in precise gene modification in plants.

Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system.

The systemic delivery of mRNA molecules to the central nervous system is challenging as they need to cross the blood-brain barrier (BBB) to reach into the brain. Here we design and synthesize 72 BBB-crossing lipids fabricated by conjugating BBB-crossing modules and amino lipids, and use them to assemble BBB-crossing lipid nanoparticles for mRNA delivery. Screening and structure optimization studies resulted in a lead formulation that has substantially higher mRNA delivery efficiency into the brain than those exhibited by FDA-approved lipid nanoparticles.