Publications by authors named "A Haselbeck"
Background: Rabies virus (RABV; species Lyssavirus rabies) is causing one of the oldest zoonotic diseases known to mankind, leading to fatal encephalomyelitis in animals and humans. Despite the existence of safe and effective vaccines to prevent the disease, an estimated 99% of human rabies deaths worldwide are caused by dog-mediated rabies with children at the highest risk of infection. Rabies has been endemic in Madagascar for over a century, yet there has been little research evaluating local knowledge and practices impacting on the rabies control and prevention.
View Article and Find Full Text PDFBackground: Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Typhoid in Africa programme was designed to address regional gaps in typhoid burden data and identify populations eligible for interventions using novel typhoid conjugate vaccines.
Methods: A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, was implemented in six countries in sub-Saharan Africa.
Article Synopsis
- Typhoid fever is a significant public health issue in sub-Saharan Africa, causing over 1.2 million illnesses and 29,000 deaths in 2017 alone.
- A study analyzed typhoid fever incidence rates from 2000 to 2022 across sub-Saharan Africa by examining the relationship between disease rates and geospatial factors like water access, sanitation, and health conditions.
- The findings showed varying incidence rates across different regions and age groups, with South Sudan reporting the highest rate, highlighting the importance of tailored interventions for disease control.
Article Synopsis
- Typhoid intestinal perforation (TIP) is a serious complication of typhoid fever, often diagnosed during surgery, leading to underreporting in regions with limited lab capabilities, such as Burkina Faso, DRC, Ethiopia, Ghana, Madagascar, and Nigeria.* ! -
- A study of 608 patients indicated that 35% had surgically-confirmed TIP, while only 5% had culture-confirmed typhoid, highlighting a low rate of detection for the disease.* ! -
- The findings suggest that low culture positivity rates and insufficient testing facilities contribute to an underestimation of typhoid fever's prevalence, with a notable occurrence of TIP in children aged 5-14 years in certain countries
Article Synopsis
- Immunizations are essential for improving community health and reducing diseases, but factors like socioeconomic status, geographic location, education, and gender create inequities in vaccine uptake, particularly in Madagascar.
- A systematic review analyzed sex-disaggregated vaccination data for children in Madagascar, searching multiple databases and including both peer-reviewed and gray literature, ultimately synthesizing data from four selected studies.
- The findings indicate that overall vaccination rates are similar between boys and girls, with some studies suggesting slightly higher rates for girls, while also identifying additional barriers to immunization such as socioeconomic status and maternal education.