Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.

Granulosa-lutein cells (GLCs) from PCOS women display reduced and levels, suggesting their role in PCOS etiology. Here, we investigated the mechanisms involved in aberrant expression in PCOS, and its association with . Various -dependent factors were studied in GLCs from PCOS and compared to normally ovulating women.

The Association between Ovarian Hyperstimulation Syndrome and Pregnancy Complications following Fertility Treatments.

Objective: This study was aimed to assess the association between ovarian hyperstimulation syndrome (OHSS) and pregnancy complications among women who conceived following fertility treatment.

Study Design: A retrospective population-based cohort study, including all singleton deliveries of patients conceived following ovulation induction (OI) or in vitro fertilization (IVF) between 1988 and 2016, was conducted. All births occurred in a single tertiary medical center.

Post-thaw culture has no beneficial effect on frozen embryos transfer outcomes comparing to same embryonal age non-cultured frozen-thawed embryos.

Purpose: To assess the impact of post-thawing embryo culture on frozen embryo transfer (FET) outcomes.

Methods: A retrospective cohort study including 678 consecutive FET cycles performed between the years 2004 and 2017 was conducted. Patients older than 45 years old were excluded.

Effects of nifedipine on endothelial function, assessed by flow-mediated vasodilatation in pregnant patients.

Objectives: To evaluate the endothelial function, through flow-mediated vasodilation parameters from brachial artery test in women receiving nifedipine for acute tocolysis with threatened preterm delivery.

Methods: In a prospective study in a university-affiliated hospital, each participant served as herself control. We evaluated various parameters of endothelial function in 22 patients between 27 and 33 weeks of gestation with a diagnosis of threatened preterm delivery (TPTD) before and after 48 h of nifedipine treatment.

Possible association between in vitro fertilization technologies and offspring neoplasm.

Objective: To study the association among fertility treatments, treatment protocol, and offspring neoplasm risk up to the age of 18 years.

Design: A population-based retrospective cohort.

Setting: Soroka University Medical Center (SUMC), the single tertiary medical center and in vitro fertilization (IVF) unit in southern Israel.