Publications by authors named "A Harford"
Article Synopsis
- Mitochondria play a crucial role in producing ATP necessary for cellular function, particularly in crucial tissues like the heart and brain, and their dysfunction at high temperatures is linked to hyperthermic death.
- As temperatures rise, the efficiency and capacity for ATP synthesis in cardiac and brain mitochondria decline, leading to insufficient ATP for cellular needs and potential organ failure.
- This commentary explores potential causes of mitochondrial failure during hyperthermia, including increased leak respiration and structural changes in the inner mitochondrial membrane that could disrupt proton transport and reduce ATP production.
Eukaryotic communities in groundwater may be particularly sensitive to disturbance because they are adapted to stable environmental conditions and often have narrow spatial distributions. Traditional methods for characterising these communities, focussing on groundwater-inhabiting macro- and meiofauna (stygofauna), are challenging because of limited taxonomic knowledge and expertise (particularly in less-explored regions), and the time and expense of morphological identification. The primary objective of this study was to evaluate the vulnerability of eukaryote communities in shallow groundwater to mine water discharge containing elevated concentrations of magnesium (Mg) and sulfate (SO).
View Article and Find Full Text PDFRationale & Objective: Reasons for transfer from peritoneal dialysis (PD) to hemodialysis (HD) remain incompletely understood. Among incident and prevalent patients receiving PD, we evaluated the association of clinical factors, including prior treatment with HD, with PD technique survival.
Study Design: Retrospective cohort study.