Publications by authors named "A Hardas"
Clonal hematopoiesis (CH) is nearly universal in the elderly. The molecular and cellular mechanisms driving CH and the clinical consequences of carrying clonally derived mutant mature blood cells are poorly understood. We recently identified a C223Y mutation in the extracellular domain (ECD) of NOTCH3 as a putative CH driver in mice.
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- * A surgical procedure called distal partial ulnectomy with ulnar styloid process excision was performed, and the biopsy confirmed it was an aneurysmal bone cyst (ABC).
- * The surgery resulted in excellent limb function with no signs of lameness or complications for up to 24 weeks, and this is the first report of this surgical approach being used in cats.
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- Gliosarcoma is a rare brain tumor in cats that has not been previously associated with changes in the hippocampus, but a case was reported involving a cat with complex partial seizures and orofacial symptoms.
- A 16-year-old cat showed symptoms like disorientation and ataxia, and MRI revealed a tumor in the right piriform lobe along with abnormalities in the hippocampus.
- Due to insufficient biomaterial, additional testing for associated conditions was not conducted, but the presence of gliosarcoma suggests that similar cases warrant MRI and antibody testing for proper diagnosis.
The thymus, a central primary lymphoid organ of the immune system, plays a key role in T cell development. Surprisingly, the thymus is quite neglected with regards to standardized pathology approaches and practices for assessing structure and function. Most studies use multispectral flow cytometry to define the dynamic composition of the thymus at the cell population level, but they are limited by lack of contextual insight.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve throughout the coronavirus disease-19 (COVID-19) pandemic, giving rise to multiple variants of concern (VOCs) with different biological properties. As the pandemic progresses, it will be essential to test in near real time the potential of any new emerging variant to cause severe disease. BA.
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