Integrated continuous melt granulation-based powder-to-tablet line: Process investigation and scale-up on the same equipment.

In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of CM lines. This research outlines the development and optimization of an integrated, polyethylene glycol aided melt granulation-based powder-to-tablet line that operates fully continuously.

Evaluation of Different Thermoanalytical Methods for the Analysis of the Stability of Naproxen-Loaded Amorphous Solid Dispersions.

The aim of this research was to investigate three thermoanalytical techniques from the glass transition temperature (T) determination point of view. In addition, the examination of the correlation between the measured T values and the stability of the amorphous solid dispersions (ASDs) was also an important part of the work. The results showed that a similar tendency of the T can be observed in the case of the applied methods.

Continuous integrated production of glucose granules with enhanced flowability and tabletability.

Glucose is widely used in both the food and pharmaceutical industry. However, the application of industrially crystallized glucose in solid dosage forms is challenged by its poor flowability and tabletability. To improve these characteristics continuous twin-screw granulation was tested, which has the potential to be integrated into the continuous production of solid glucose from corn starch.

[Sweet syndrome following therapeutic use of granulocyte colony stimulating factor].

Sweet's syndrome is an acute febrile neutrophilic dermatosis. Classical form occurs after infection of the gastrointestinal or respiratory tract. This syndrome is often associated with myeloproliferative disorders and solid tumors.

[Changes in indications for liver biopsy].

The author tries to analyse the modification of the indication to the needle biopsy of the liver. The clinician still only rarely demands from the pathologist the verification of an acute hepatitis and the proof of an obstruction. On the other hand a differentiation of persisting and aggressive hepatitis is possible only by a morphological investigation.