Publications by authors named "A Hara"
Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM). We previously identified alternative splicing promoting the PKM2 isoform after myocardial infarction (MI). We examined the role of PKM2 physiological upregulation after MI, modeled by ligation of the left anterior descending coronary artery, using global PKM2 knockout (PKM2) mice.
View Article and Find Full Text PDFObjectives: Daily-use fluoride products are first-line protection against enamel wear from dietary-acid exposure (DAE). This study aimed to understand effects of fluoride concentration, fluoride salt, product form and ingredients in daily-use products on remineralisation and demineralisation, via network meta-analysis (NMA) of 14 studies using one well-established in-situ model. Remineralisation (surface-microhardness recovery, SHMR) after treatment, and protection against subsequent demineralisation (acid-resistance ratio, ARR) were measured.
View Article and Find Full Text PDFPrcis: Trabeculectomy increases tissue blood flow superior and temporal in the optic nerve head. Improvement of tissue blood flow superior and temporal in the optic nerve could be an indicator of the effectiveness of glaucoma treatment.
Purpose: To investigate changes in tissue blood flow at the optic nerve head before and after trabeculectomy.
Article Synopsis
- Silver Diamine Fluoride (SDF) is an effective, non-invasive treatment for dental caries but causes tooth discoloration, which affects patient acceptance.
- This study investigates how Zinc can help reduce discoloration caused by SDF while preserving the physical properties of dentin, such as hardness and roughness.
- Results show that higher concentrations of Zinc significantly decreased SDF-induced discoloration without adversely affecting dentin properties, suggesting potential for better patient acceptance in cosmetic dental treatments.
Context: Oxytocin supplementation improves obstructive sleep apnea (OSA), and animal studies suggest involvement of oxytocin in respiratory control. However, the relationship between endogenous oxytocin signaling and human sleep status remains undetermined.
Objective: In this study, we approached the contribution of the intrinsic oxytocin-oxytocin receptor (OXTR) system to OSA by genetic association analysis.