Publications by authors named "A Hankard"
Article Synopsis
- Neutrophil subsets with regulatory properties are often seen as harmful to immune responses against tumors and infections, but new findings suggest otherwise in cases of severe viral respiratory infections (VRI).
- A significant population of neutrophils expressing programmed death-ligand 1 (PD-L1) was identified in humans and mice with VRI, exhibiting strong regulatory functions but diminished antimicrobial capabilities.
- Depleting these PD-L1 neutrophils or blocking their function during VRI led to worse outcomes, indicating that they play a crucial role in managing inflammation and could be potential targets for future treatments.
Objective: To assess the prognosis and outcome of patients with isolated carotid vasculitis.
Methods: We performed a retrospective multicenter study of 36 patients (median age at diagnosis was 37 [IQR 27-45] years and 11 [31 %] patients were men) with initial presentation as isolated carotid vasculitis. Study endpoints included vascular complications, relapses, and progression to large vessel vasculitis (i.
ADULT IGA VASCULITIS. IgA vasculitis previously named rheumatoid purpura is a rare systemic vasculitis in adults involving small vessels and associated with the presence of immunoglobulin A deposits. IgA vasculitis is often triggerd by infections, taking medication and vaccination.
View Article and Find Full Text PDFImpact of gender on baseline presentation and outcome in adult IgA vasculitis.
Rheumatology (Oxford)
January 2025
Article Synopsis
- This study analyzed the impact of gender on adult IgA vasculitis (IgAV) by examining data from 260 patients across multiple centers.
- Results showed that while baseline symptoms were similar between males and females, males experienced more severe kidney involvement, indicated by lower kidney function and higher protein levels in urine.
- Male patients also received more aggressive treatments but had a higher rate of refractory disease, suggesting gender could be a significant prognostic factor in the disease's progression.
IgA vasculitis (IgAV) is a small size vasculitis for which epidemiologic data are strikingly lacking, especially about the adult form. Additionally, the COVID-19 pandemic seems to have profoundly modified the incidence of this disease. Here, we aimed to establish some relevant epidemiological data in both pediatric and adult IgAV.
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