Publications by authors named "A Hampshire"
Online cognitive tasks are gaining traction as scalable and cost-effective alternatives to traditional supervised assessments. However, variability in peoples' home devices, visual and motor abilities, and speed-accuracy biases confound the specificity with which online tasks can measure cognitive abilities. To address these limitations, we developed IDoCT (Iterative Decomposition of Cognitive Tasks), a method for estimating domain-specific cognitive abilities and trial-difficulty scales from task performance timecourses in a data-driven manner while accounting for device and visuomotor latencies, unspecific cognitive processes and speed-accuracy trade-offs.
View Article and Find Full Text PDFBackground: Telomere length (TL) has been linked to cognitive function, decline and dementia. This study aimed to explore whether both measured TL and genetic disposition for TL predict dimensions of cognitive performance in a longitudinal sample of older UK adults.
Methods: We analysed data from PROTECT study participants aged ≥50 years without a dementia diagnosis, who had completed longitudinal cognitive testing.
Linking cognitive and behavioral reserve: Evidence from the CAN-PROTECT study.
Alzheimers Dement (N Y)
October 2024
Article Synopsis
- Changes in the brain from Alzheimer's and other age-related diseases can cause problems with thinking and behavior, even before serious symptoms appear.
- The study looked at how a person's cognitive reserve (a mix of education and experiences) relates to mild behavioral issues.
- Results showed that people with a higher cognitive reserve had better brain test scores and fewer behavior problems, which suggests that keeping mentally active might help both thinking and behavior as we get older.
Article Synopsis
- * Results showed that infected volunteers had significantly lower cognitive scores compared to their uninfected counterparts, particularly in tasks related to memory and executive function.
- * Despite the cognitive score differences, none of the volunteers reported ongoing subjective cognitive symptoms even after the study period of up to 360 days post-infection.
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19.
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