Absolute bioavailability, pharmacokinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmine-bromide in healthy volunteers.

Aim: The aim of the study was to determine the absolute bioavailability and pharmacokinetics after a single dose oral administration in comparison to i.v. administration of 14C-labelled distigmine-bromide (14C-Ubretid) in healthy male volunteers.

Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs.

A clinical study was performed on 18 healthy volunteers to compare the gastrointestinal daily blood loss induced by oral intake of three different non-steroidal anti-inflammatory drugs, lysine clonixinate (CAS 55837-30-4), ibuprofen (CAS 15687-27-1) and acetylsalicylic acid (CAS 50-78-2 ASA). For quantitative determination of gastrointestinal blood loss, autologous erythrocytes were radiolabelled in vitro with 51Cr and reinfused at study start. The amount of radioactivity excreted in faeces was measured during a placebo baseline phase of three days, a treatment phase of five days with thrice daily dosing of ASA, ibuprofen or lysine clonixinate and a subsequent wash-out phase of five days.

Radiochemical purity and in vitro stability of commercial hippurans.

Good radiochemical purity of hippuran is important regarding the patient's radiation dose, primarily because of the high thyroid exposure from free iodide. The radiochemical purity and in vitro stability of 11 commercially available 131I, 125I, and 123I hippurans were analyzed by means of thin layer chromatography. Three different radioactive impurities were found in all hippuran samples: (a) free radioiodide, (b) a radiochemical impurity that has been unknown up until now, and (c) labeled o-iodobenzoic acid.

Chemical, radiochemical, and radionuclide purity of eluates from different commercial fission 99Mo/99mTc generators.

Seven 99Mo/99mTc generators (using fission 99Mo) obtained from seven different manufacturers were studied in 1984 and 1985 to test the quality of the eluates. We present the findings concerning the elution efficiency, radionuclide purity, 99Mo breakthrough, radiochemical purity, pH, and aluminium content of the eluates. One generator was overloaded with 99Mo by about 40%, while one generator had 99mTc yields of only about 80%.

[Radiochemical purity studies on 10 radiopharmaceuticals].

Ten radiopharmaceuticals in frequent clinical use were examined for their radiochemical purity. Thin-layer chromatography, paper chromatography and electrophoresis were used. The activity of the separated components was measured in a gamma sample changer.