Publications by authors named "A Hamid Zargar"
Adverse cardiovascular (CV) events have declined in Western countries due at least in part to aggressive risk factor control, including dyslipidemia management. The American and European (Western) dyslipidemia treatment guidelines have contributed significantly to the reduction in atherosclerotic cardiovascular disease (ASCVD) incidence in the respective populations. However, their direct extrapolation to Indian patients does not seem appropriate for the reasons described below.
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- Fatty liver disease is divided into two types: metabolic dysfunction-associated fatty liver disease (MAFLD) and non-MAFLD, with the TGF-β signaling pathway playing a crucial role in its development.
- In a study comparing 41 patients with fatty liver (22 with MAFLD, 19 with non-MAFLD) to 22 healthy controls, significant changes were observed in gene and protein expressions related to the TGF-β pathway.
- Results indicated decreased expressions of TGF-β1 and TGF-β3 and an increase in CTGF, with notable differences in Smad2/3 protein levels between the two patient groups, suggesting metabolic factors primarily influence TGF-β1
Article Synopsis
- - Cardiovascular diseases (CVDs) cause 17.9 million deaths annually, making up 31% of global fatalities, highlighting their severe impact on public health.
- - The study focused on diabetic and nondiabetic patients with CVD at Guru Gobind Singh Medical College and Hospital, assessing risk factors using the Framingham Risk Scale and Cholesterol Risk Calculator.
- - Results indicated that higher Framingham Risk Scores correlated with factors like gender, calorie intake, physical activity, and lipid profiles, suggesting patients with elevated scores face increased risks for diabetes and CVD.
Diabetes Mellitus and Fluid Imbalance: The Need for Adequate Hydration.
J Assoc Physicians India
June 2024
Article Synopsis
- Hydration plays a crucial role in reducing the risk of metabolic diseases, especially for diabetic patients, who are more prone to dehydration due to osmotic diuresis.
- Increased blood sugar levels can lead to imbalances in electrolytes and affect how the kidneys handle fluids.
- Various factors, like exercise, heat, alcohol, and illness, further heighten the risk of dehydration, making it essential for diabetic patients to maintain proper hydration and electrolyte levels.
Crohn's disease (CD) is a chronic and debilitating inflammatory bowel disease that affects millions of individuals worldwide. Despite the availability of various treatment options, a significant number of patients do not achieve remission or experience adverse effects with conventional therapies. Vedolizumab, a novel therapeutic agent, has emerged as a promising approach in the management of CD.
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