Publications by authors named "A Hamamura"
Background: Diffuse intrinsic pontine glioma (DIPG) stands as the predominant type of brainstem glioma. It is characterized by a notably brief median survival period, with the majority of patients experiencing disease progression within six months following radiation therapy. This systematic review and meta-analysis aims to assess the efficacy and safety of hypofractionated radiotherapy (HFRT) compared to conventionally fractionated radiotherapy (CFRT) in DIPG treatment.
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- - A 63-year-old man with adult T-cell leukemia-lymphoma received a bone marrow transplant from an unrelated donor and was later diagnosed with invasive pulmonary aspergillosis (IPA) 17 days post-transplant.
- - He initially improved with treatment using liposomal amphotericin B, but was switched to voriconazole due to worsening kidney function, and later experienced neurological issues.
- - The patient passed away on day 62, with an autopsy revealing fungal infection in the lungs and a ruptured cerebral aneurysm, emphasizing the need for careful monitoring of transplant patients for fungal-related complications.
Article Synopsis
- Caplacizumab, a therapy for immune-mediated thrombotic thrombocytopenic purpura (iTTP), shows benefits in achieving quicker platelet counts but is linked to slower recovery of ADAMTS13 activity.
- A study compared acute iTTP patients treated with and without caplacizumab, highlighting that those on caplacizumab took longer to normalize ADAMTS13 activity, with significant differences in inhibitor levels and antibody titers.
- The findings suggest that while caplacizumab helps improve platelet counts faster, it may delay the recovery of ADAMTS13 due to fewer plasma exchanges and later administration of rituximab.
An 18-year-old man underwent allogenic bone marrow transplantation (BMT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). Ph+ALL relapsed 3 months after the first BMT, and the patient underwent a second BMT. However, Ph+ALL relapsed 4 months after the second BMT, and he received a haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) from his father.
View Article and Find Full Text PDFPurpose: The efficacy and safety of stereotactic body radiation therapy (SBRT) for patients with nonspine bone metastases remains in question. A systematic review and meta-analysis were performed to evaluate SBRT treatment outcomes in nonspine bone metastases.
Methods And Materials: Eligible studies were retrieved from MEDLINE, Embase, Scielo, the Cochrane Library, and annual meeting proceedings through July 6, 2023.