Publications by authors named "A Hakem"
Article Synopsis
- Cutaneous leishmaniasis is a global public health issue, and this study focuses on its effect on patients' quality of life in the Draa-Tafilalet region of Morocco.
- Researchers gathered data from 87 patients using the Skindex-16 questionnaire, finding that 73.6% reported a moderate impact on their quality of life, with more females affected than males.
- The presence of facial lesions significantly worsened quality of life, particularly in emotional and functioning aspects, indicating a need for specific management strategies and further research to understand these effects better.
Article Synopsis
- Crimean-Congo hemorrhagic fever (CCHF) is a viral disease transmitted by ticks, and its prevalence in northern Africa, particularly Algeria, is not well understood.
- A study was conducted on 269 camels in southern Algeria to determine CCHFV antibodies, revealing a high seroprevalence rate of 94.8%.
- The presence of ticks was identified as a significant risk factor for CCHF exposure in camels, urging further research on CCHFV's impact on humans, animals, and ticks in the region.
Scorpion envenomation (SE) is a critical and immediate medical emergency. It represents a major public health concern with significant cause of illness and death, particularly in rural regions where scorpions are more prevalent. Of note, administering appropriate first aid to scorpion sting victims is one of the most effective ways to reduce mortality.
View Article and Find Full Text PDFArticle Synopsis
- Bluetongue (BT) is a viral disease affecting various ruminants across Africa, but data on its prevalence is limited, prompting a systematic review and meta-analysis.
- The study found a pooled seroprevalence of the bluetongue virus (BTV) to be 45.02%, with higher rates seen in cattle (49.70%) and goats (47.00%), particularly in the southeastern region of Africa.
- It was noted that female animals showed a significantly higher seroprevalence (53.30%) compared to males (28.10%), highlighting the need for ongoing monitoring and surveillance to prevent the disease's spread.
PARP inhibitors (PARPi) are efficacious in -null tumors; however, their utility is limited in tumors with functional BRCA1. We hypothesized that pharmacologically reducing BRCA1 protein levels could enhance PARPi effectiveness in wild-type tumors. To identify BRCA1 downregulating agents, we generated reporter cell lines using CRISPR-mediated editing to tag endogenous BRCA1 protein with HiBiT.
View Article and Find Full Text PDF