Publications by authors named "A Haimovitz-Friedman"
Article Synopsis
- The study examines the role of acid sphingomyelinase (ASMase) in the effectiveness of radiation therapy against tumors, highlighting its importance in tumor radiocurability and immune response.
- The researchers used Lewis Lung Carcinoma (LLC) cells in different mouse models to observe how ASMase affects tumor response to radiation, including immune cell infiltration and related signaling pathways.
- Findings revealed that ASMase is crucial for a successful immune response to radiation, as tumors in ASMase knockout mice did not respond effectively, underscoring the importance of ASMase in mediating radiation-induced anti-tumor immunity through STING activation.
Article Synopsis
- Spatially fractionated radiotherapy (SFRT) is a treatment method that uses techniques to create areas of low radiation dose alongside high doses, aiming to boost the immune response that might be weakened by standard radiation.
- This approach has shown to produce significant tumor shrinkage in patients with large, challenging tumors, and preclinical studies suggest it can achieve complete tumor removal and enhance overall immune function.
- Current clinical trials are exploring the effectiveness and safety of SFRT, especially when combined with immunotherapy, demonstrating promising preliminary results.
Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann-Pick type A (NPA) is a fatal neurodegenerative lysosomal storage disease characterized by abnormal sphingomyelin accumulation in the endolysosomal lumen. The ability to monitor abnormalities in lipid homeostasis intracranially could improve basic investigations and the development of effective treatment strategies.
View Article and Find Full Text PDFActivation of STING in Response to Partial-Tumor Radiation Exposure.
Int J Radiat Oncol Biol Phys
November 2023
Purpose: To determine the mechanisms involved in partial volume radiation therapy (RT)-induced tumor response.
Methods And Materials: We investigated 67NR murine orthotopic breast tumors in Balb/c mice and Lewis lung carcinoma (LLC cells; WT, Crispr/Cas9 Sting KO, and Atm KO) injected in the flank of C57Bl/6, cGAS, or STING KO mice. RT was delivered to 50% or 100% of the tumor volume using a 2 × 2 cm collimator on a microirradiator allowing precise irradiation.