Publications by authors named "A Hagendorff"

Article Synopsis
  • - Sacubitril/valsartan significantly improves outcomes in patients with chronic heart failure and reduced ejection fraction, enhancing left ventricular (LV) function over six months of treatment.
  • - Key improvements were observed, including increased LV contractility (Ees), decreased afterload (Ea), and enhanced ventricular-arterial coupling ratio (Ea/Ees), along with a notable increase in left ventricular ejection fraction (LVEF) from 33% to 43%.
  • - The study found positive correlations between changes in LVEF and LV contractility, as well as between NT-proBNP levels and left ventricular end-diastolic pressure (LVEDP), suggesting these factors play a role in the treatment's effectiveness
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Article Synopsis
  • Left atrial strain (LAS) assessment via speckle tracking echocardiography (STE) is useful for detecting left ventricular (LV) issues, particularly in athletes during treadmill exercise tests.
  • A study involving 50 male athletes examined LAS in both upright and left lateral positions, measuring various echocardiographic parameters.
  • Results showed that LAS metrics and maximum left atrial volume were significantly lower in the upright position compared to the left lateral position, suggesting that posture impacts LA function and should be considered in echocardiography for athletes.
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The left atrial appendage is a blind ending cardiac structure prone to blood stasis due to its morphology. This structure is a preferred region of thrombogenesis in relation to reduced myocardial contractility of the atrial wall. Blood stasis occurs primarily in low flow conditions.

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Article Synopsis
  • The study investigates the connection between deep vein thrombosis (DVT) and cerebral ischemia in patients with a patent foramen ovale (PFO), noting a lack of consistent data and screening recommendations in past research.
  • Medical records of 339 stroke or transient ischemic attack (TIA) patients with PFO were analyzed, revealing a 7.8% occurrence of DVT, which was associated with several health factors, including a history of DVT, cancer, and specific clinical signs.
  • The findings suggest that DVT is common in these patients and recommend using the Wells score as a significant predictor for DVT, guiding further diagnostic tests like compression ultrasonography.
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Echocardiography in patients with atrial fibrillation is challenging due to the varying heart rate. Thus, the topic of this expert proposal focuses on an obvious gap in the current recommendations about diagnosis and treatment of atrial fibrillation (AF)-the peculiarities and difficulties of echocardiographic imaging. The assessment of systolic and diastolic function-especially in combination with valvular heart diseases-by echocardiography can basically be done by averaging the results of echocardiographic measurements of the respective parameters or by the index beat approach, which uses a representative cardiac cycle for measurement.

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