Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different?

There are similarities in the pathophysiologic mechanisms of atherosclerosis, calcific aortic valve disease (CAVD) and mitral annular calcification (MAC), however, medical treatment to slow or stop the progression of CAVD or MAC has been more elusive as compared to atherosclerosis. Atherosclerosis and CAVD share common demographic, clinical, protein, and genetic factors even more so than with MAC, which supports the possibility of shared medical therapies, though abrogating calcific extracellular vesicle shedding could be a common target for all three conditions. Herein, we summarize the overlapping and distinct pathways for further investigation, as well as key areas where additional research is needed.

Foam fractionation studies of recombinant human apolipoprotein A-I.

Apolipoprotein A-I (apoA-I), the primary protein component of plasma high-density lipoproteins (HDL), is comprised of two structural regions, an N-terminal amphipathic α-helix bundle domain (residues 1-184) and a hydrophobic C-terminal domain (residues 185-243). When a recombinant fusion protein construct [bacterial pelB leader sequence - human apoA-I (1-243)] was expressed in Escherichia coli shaker flask cultures, apoA-I was recovered in the cell lysate. By contrast, when the C-terminal domain was deleted from the construct, large amounts of the truncated protein, apoA-I (1-184), were recovered in the culture medium.

An in-depth analysis of membrane distillation research (1990-2023): Exploring trends and future directions through bibliometric approach.

This bibliometric analysis offers a comprehensive investigation into membrane distillation (MD) research from 1990 to 2023. Covering 4389 publications, the analysis sheds light on the evolution, trends, and future directions of the field. It delves into authorship patterns, publication trends, prominent journals, and global contributions to reveal collaborative networks, research hotspots, and emerging themes within MD research.

Unlocking groundwater desalination potential for agriculture with fertilizer drawn forward osmosis: prediction and performance optimization via RSM and ANN.

The agricultural sector uses 70% of the world's freshwater. As clean water is extracted, groundwater quality decreases, making it difficult to grow crops. Brackish water desalination is a promising solution for agricultural areas, but the cost is a barrier to adoption.