Publications by authors named "A Haferkamp"
Penile cancer (PeCa) is a rare disease with poor prognosis in the metastatic stage. Neither effective adjuvant nor palliative therapeutic options are available. Research efforts in this field have so far failed to establish robust predictors of survival.
View Article and Find Full Text PDF: Plant derived isolated compounds or extracts enjoy great popularity among cancer patients, although knowledge about their mode of action is unclear. The present study investigated whether the combination of two herbal drugs, the cyanogenic diglucoside amygdalin and the isothiocyanate sulforaphane (SFN), influences growth and proliferation of renal cell carcinoma (RCC) cell lines. : A498, Caki-1, and KTCTL-26 cells were exposed to low-dosed amygdalin (1 or 5 mg/mL), or SFN (5 µM) or to combined SFN-amygdalin.
View Article and Find Full Text PDFTransglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- Tissue transglutaminase 2 (TGM2) and matrix metalloproteinase 7 (MMP7) play critical roles in colon cancer development, influencing epithelial-mesenchymal transition (EMT), which is crucial for cancer cell invasion and migration.
- This study shows that overexpressing TGM2 enhances MMP7 activity, promoting invasive behaviors of colon cancer cells, while knocking down TGM2 has the opposite effect.
- The research suggests that targeting TGM2 may provide a new therapeutic approach to hinder the progression of colon cancer by affecting the MEK/ERK signaling pathway and EMT processes.
Radical cystectomy in patients aged < 80 years versus ≥ 80 years: analysis of preoperative geriatric assessment scores in predicting postoperative morbidity and mortality.
World J Urol
September 2024
Purpose: Pre-operative assessment of surgical risk is essential for patient counselling in the elderly patient population. Our purpose was to compare validated geriatric assessment scores (GAS) in predicting postoperative morbidity and mortality in patients ≥ 80 years.
Methods: Overall, eight preoperative GAS were assessed for each patient who received RC from 2016 to 2021.
Resistance to antiandrogens and chemotherapy (Cx) limits therapeutic options for patients with metastatic hormone-sensitive (mHSPC) and metastatic castration-resistant (mCRPC) prostate cancer. In this context, up-regulation of the glucocorticoid receptor is identified as a potential bypass mechanism in mCRPC. A combination of docetaxel and mifepristone (Doc + RU-486), an inhibitor of the glucocorticoid receptor, re-sensitizes docetaxel-resistant cell models to Cx.
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