Management and functional outcomes of a pipkin type II fracture: A case report.

Introduction: Femoral head (Pipkin) fractures are rare injuries typically caused by high-energy trauma. Classified into four types, their management remains debated, particularly for Pipkin type II fractures. This case report provides insights into surgical treatment, rehabilitation, and associated complications.

Effect of Peri-Interventional Blood Loss on In-Stent Thrombosis After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.

This paper evaluates the effect of blood loss on in-stent stenosis after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Nine hundred and ninety-seven patients who underwent PCI for AMI as well as follow-up coronary angiography at 6-12 months from two centers were categorized into three groups based on peri-interventional blood loss at the primary intervention (mild, <1 mmol/L moderate, 1-2 mmol/L; severe > 2 mmol/L). The endpoint was to evaluate the incidence and severity of in-stent stenosis at follow-up angiography and the revascularization rate.

Lack of Pharmacokinetic Drug-Drug Interactions Between Bepirovirsen and Nucleos(t)ide Analogs.

Bepirovirsen is an antisense oligonucleotide currently in Phase 3 development to treat chronic hepatitis B virus (HBV) infection. Given the importance of coadministration of bepirovirsen and standard-of-care nucleos(t)ide analogs (NAs), we evaluated drug-drug interactions (DDIs) between bepirovirsen, entecavir (ETV), and tenofovir (TFV) using in vitro and clinical data obtained through innovative study design and sampling strategy. Static models employing in vitro data indicated that bepirovirsen is not a direct inhibitor or inducer of most drug-metabolizing enzymes or an inhibitor or substrate of drug transporters and poses no clinical DDI risk against NAs.

Smart building energy management with renewables and storage systems using a modified weighted mean of vectors algorithm.

With the advancement of automation technologies in household appliances, the flexibility of smart home energy management (EM) systems has increased. However, this progress has brought about a new challenge for smart homes: the EM has become more complex with the integration of multiple conventional, renewable, and energy storage systems. To address this challenge, a novel modified Weighted Mean of Vectors algorithm (MINFO) is proposed.