Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial.

Malaria vaccines consisting of metabolically active Plasmodium falciparum (Pf) sporozoites can offer improved protection compared with currently deployed subunit vaccines. In a previous study, we demonstrated the superior protective efficacy of a three-dose regimen of late-arresting genetically attenuated parasites administered by mosquito bite (GA2-MB) compared with early-arresting counterparts (GA1-MB) against a homologous controlled human malaria infection. Encouraged by these results, we explored the potency of a single GA2-MB immunization in a placebo-controlled randomized trial.

Correction: Different cadences and resistances in sub-maximal synchronous handcycling in able-bodied men: Effects on efficiency and force application.

[This corrects the article DOI: 10.1371/journal.pone.

Effective realization of abatement measures can reduce HFC-23 emissions.

HFC-23 is a potent greenhouse gas, predominantly emitted as an undesired by-product during the synthesis and processing of HCFC-22 (ref. ). Previously, the Clean Development Mechanism and national efforts called for the implementation of abatement technology for reducing HFC-23 emissions.

Utilizing the 'Iowa Model Revised: Evidence-Based Practice' to Develop an Intervention for Use in a Hemodialysis Setting.

The development of nursing evidence within hemodialysis is challenged by the vast numbers of specialized tasks clinicians undertake. Developing an evidence base is complex and multi-faceted, requiring a collaborative and well-defined process. Commonly, a process of quality improvement is initially undertaken, whereby nurses develop a plan, undertake action, study outcomes, and review results.