Publications by authors named "A H van Vugt"

Article Synopsis
  • The integration of metal nanoparticle films onto 3D-structured PDMS microfluidic devices is crucial for various applications like electronics and sensing.
  • Traditional methods for depositing these nanoparticles are complex, costly, and often require cleanroom facilities.
  • An innovative aerosol-based direct-write technique allows precise nanoparticle patterns to be printed inside microfluidic structures without the need for lithography, demonstrating successful applications in electrochemical screening and localized chemical sensing.
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Article Synopsis
  • Two cases of men aged 26 and 55 highlight the complexity of patients with Medically Unexplained Symptoms (MUS) where initial diagnoses were missed.
  • The first patient had significant mobility issues and depression attributed to a functional neurological disorder, but was later found to have avascular necrosis of the femoral head and is now recovering post-surgery.
  • The second patient experienced a decade of sexual and bladder dysfunction, with recent issues in walking, speaking, and swallowing, ultimately diagnosed with multiple system atrophy, leading to better acceptance of his condition after a referral to a specialist.
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Background: Sacroiliac joint dysfunction (SJD) is a known cause of lower back pain. SJD might be due to hypermobility in the Sacroiliac joint (SIJ) in patients with Ehlers Danlos Syndrome (EDS). Stabilization of the SIJ can be a highly successful treatment for lower back pain.

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Article Synopsis
  • Gain-of-function mutations in guanylyl cyclase C (GCC) lead to persistent diarrhea from birth, and a study explores the GCC inhibitor SSP2518 as a treatment option.
  • The research tested SSP2518's effects on cGMP levels and chloride secretion in intestinal organoids sourced from patients with GCC mutations compared to control organoids.
  • Results showed that SSP2518 lowered cGMP levels in patient organoids to match controls and significantly reduced chloride secretion, suggesting it could help manage diarrhea linked to GCC mutations.
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