Publications by authors named "A H Zwinderman"
Background: Resveratrol, a dietary supplement that intervenes in cellular metabolism, has been shown to reduce aortic growth rate in a mouse model of Marfan syndrome (MFS), a condition associated in humans with life-threatening aortic complications, often preceded by aortic dilatation. The primary objective of this study was to investigate the effects of resveratrol on aortic growth rate in patients with MFS .
Methods: In this investigator-initiated, single-arm open-label multicentre trial, we analysed resveratrol treatment in adults aged 18-50 years with MFS.
Background: High heritability of salt sensitivity suggests an essential role for genetics in the relationship between sodium intake and blood pressure (BP). The role of glycosaminoglycan genes, which are crucial for salinity tolerance, remains to be elucidated.
Methods: Interactions between 54 126 variants in 130 glycosaminoglycan genes and daily sodium excretion on BP were explored in 20 420 EPIC-Norfolk (European Prospective Investigation Into Cancer in Norfolk) subjects.
Article Synopsis
- Individual participant data (IPD) meta-analysis allows for better understanding of interaction and effect modification compared to traditional studies, especially in public health contexts.
- The text emphasizes the importance of focusing on additive interactions rather than just multiplicative ones, particularly using measures like Relative Excess Risk due to Interaction (RERI).
- A three-step method is proposed to correctly estimate additive interaction across studies, ensuring valid results when analyzing factors like the link between depression, smoking, and cancer risk using available data.