Soil quality indicator-based land productivity modelling for agricultural sustainability.

Rapid population expansion has made food security a global concern for humanity, necessitating a sustainable assessment of natural resources. Well evaluated and managed soil is one of the most significant resources that can assist close the gap between supply and demand for food to attain food security. A precise assessment of land productivity (LP) is essential for sustainable land use management.

Titanium nanostructure mitigating doxorubicin-induced testicular toxicity in rats via regulating major autophagy signaling pathways.

Doxorubicin (DOX) is a powerful antineoplastic FDA-approved anthracycline-derived antibiotic and is considered as the most suitable intervention for solid tumors and hematological cancers therapy. However, its therapeutic application is highly limited due to acute and chronic renal, hematological and testicular toxicity. Oxidative stress, lipid peroxidation and apoptosis in germ cells as well as low sperm count, motility and disturbing steroidogenesis are the principal machineries of DOX-induced testicular toxicity.

Drug toxicity prediction model based on enhanced graph neural network.

Prediction of drug toxicity remains a significant challenge and an essential process in drug discovery. Traditional machine learning algorithms struggle to capture the full scope of molecular structure features, limiting their effectiveness in toxicity prediction. Graph Neural Network offers a promising solution by effectively extracting drug features from their molecular graphs.

Mining of latent feruloyl esterase resources in rumen and insight into dual-functional feruloyl esterase-xylanase from Pecoramyces ruminantium F1.

Feruloyl esterase (FAE) has been extensively studied for its crucial auxiliary effect in the biodegradation of lignocellulose. In this study, a FAE database including 15,293 amino acid sequences was established to gain a better understanding of rumen FAEs through multi-omics analysis. The higher expression level of rumen fungal FAEs over bacterial FAEs suggests that rumen fungi may have more important role in the lignocellulose degradation.

Correction: Design, synthesis, pharmacological evaluation, and studies of the activity of novel spiro pyrrolo[3,4-]pyrimidine derivatives.

[This corrects the article DOI: 10.1039/D3RA07078F.].