Publications by authors named "A H Yen"
Some scholars have suggested that social and cultural barriers between physicians and patients might contribute to health disparities. The purpose of this review was to determine the state of evidence regarding how physician communication patterns differ by patient ethnicity. Seventy-nine studies employing a range of methodologies were identified.
View Article and Find Full Text PDFProgression-Free Survival Prediction for Locally Advanced Cervical Cancer After Chemoradiotherapy With MRI-based Radiomics.
Clin Oncol (R Coll Radiol)
November 2024
Article Synopsis
- A study focuses on predicting progression-free survival (PFS) in patients with locally advanced cervical cancer (LACC) after chemoradiotherapy using a radiomics-based model based on MR T2-weighted imaging.
- The study involved analyzing MR images from 105 LACC patients, utilizing Cox proportional hazard modeling and cross-validation methods to create a combined model that incorporates both radiomics and clinical variables.
- Results showed that the radiomics feature significantly outperformed models using only clinical variables, enhancing the ability to differentiate between high- and low-risk patients for disease progression, indicating the potential of MR T2WI radiomics as a valuable imaging biomarker in personalized treatment strategies.
Mutations reducing the function of MYT1L, a neuron-specific transcription factor, are associated with a syndromic neurodevelopmental disorder. MYT1L is used as a pro-neural factor in fibroblast-to-neuron transdifferentiation and is hypothesized to influence neuronal specification and maturation, but it is not clear which neuron types are most impacted by MYT1L loss. In this study, we profile 412,132 nuclei from the forebrains of wild-type and MYT1L-deficient mice at three developmental stages: E14 at the peak of neurogenesis, P1 when cortical neurons have been born, and P21 when neurons are maturing, to examine the role of MYT1L levels on neuronal development.
View Article and Find Full Text PDFAirway Mucus Plugs on Chest Computed Tomography Are Associated with Exacerbations in COPD.
Am J Respir Crit Care Med
October 2024
Unlabelled: Rationale/Objective: Acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) are associated with significant morbidity and mortality. Whether mucus plugs are associated with prospective exacerbations has not been examined extensively.
Methods: Mucus plugs were visually-identified on baseline chest computed tomography (CT) scans from smokers with Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 2-4 COPD enrolled in two multicenter cohort studies: Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) and COPDGene.