Publications by authors named "A H Welsh"
High-throughput combinatorial metal complex synthesis has emerged as a powerful tool for rapidly generating and screening diverse libraries of metal complexes, enabling accelerated discovery in fields such as catalysis, medicinal chemistry, and materials science. By systematically combining building blocks under mild and efficient conditions, researchers can explore broad chemical spaces, increasing the likelihood of identifying complexes with desired properties. This method streamlines hit identification and optimisation, especially when integrated with high-throughput screening and data-driven approaches like machine learning.
View Article and Find Full Text PDFAnnual Research Review: Micronutrients and their role in the treatment of paediatric mental illness.
J Child Psychol Psychiatry
December 2024
The aim of this narrative review is to summarize evidence relating the importance of nutrient intake from diet and supplementation for paediatric mental health. We begin by reviewing several mechanisms by which nutrients maximize brain health, including enabling metabolic reactions to occur, supporting mitochondrial function, reducing inflammation and assisting with detoxification. Circumstances that may contribute to an individual requiring additional nutrients beyond what are available in the diet, such as consumption of nutritionally depleted food, individual differences in biological need, long-term medication use and gut-brain health needs are then reviewed.
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- Patients post-hip fracture often experience fragmented care and poor discharge planning, highlighting the need for improved patient flow and transition support from hospital to home.* -
- A qualitative study involving interviews with patients, carers, and health professionals revealed challenges such as ineffective communication and disjointed services during discharge, along with the complexity of recovery beyond just the physical injury.* -
- Solutions suggested include better reassurance, collaborative planning, and personalized care to help patients and their supporters navigate the transition more effectively, ultimately aiming for a more coordinated approach in discharge planning.*
Article Synopsis
- The study aimed to determine how many pulsed-wave Doppler (PWD) waveforms need to be averaged to minimize variability in Doppler indices during uncomplicated singleton pregnancies.
- A total of 189 pregnancies were analyzed, focusing on the umbilical artery, middle cerebral artery, and uterine arteries, with findings showing that the pulsatility index (PI) was more variable than the resistance index (RI).
- To achieve a 5% variability in PI, at least 14 waveforms needed to be averaged for both UA and MCA, while the RI required only 2 for UA, 1 for MCA, and 8 for UtAs, suggesting that RI may be a more stable indicator for maternal-fetal Doppler assessments
Deep learning (DL) tools developed on adult data sets may not generalize well to pediatric patients, posing potential safety risks. We evaluated the performance of TotalSegmentator, a state-of-the-art adult-trained CT organ segmentation model, on a subset of organs in a pediatric CT dataset and explored optimization strategies to improve pediatric segmentation performance. TotalSegmentator was retrospectively evaluated on abdominal CT scans from an external adult dataset (n = 300) and an external pediatric data set (n = 359).
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