Publications by authors named "A H Van Craenenbroeck"

Patients with a Fontan circulation are at risk for chronic kidney disease (CKD), which is defined as persistently reduced glomerular filtration rate (GFR) <60ml/min/1.73 or elevated marker of kidney injury such as urinary albumin-to-creatinine ratio (UACR) >30mg/g. We determined the prevalence of albuminuria in patients with a Fontan circulation.

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The retina allows noninvasive in vivo assessment of the microcirculation. Autoregulation of the retinal microvasculature meets the changing requirements of local metabolic demand and maintains adequate blood flow. Analysis of the retinal vascular reactivity contributes to the understanding of regulatory physiology and its relationship to the systemic microcirculation.

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Article Synopsis
  • Kidney structural cells actively participate in the rejection process of kidney transplants, alongside infiltrated immune cells, as shown through single-cell RNA sequencing of biopsies.
  • Upregulation of immune-related genes was observed in endothelial and epithelial cells, indicating their involvement in the alloimmune response, with distinct differences based on the kidney compartment.
  • A significant downregulation of energy metabolism in proximal tubular cells during inflammation correlates with reduced kidney function, emphasizing the graft's crucial role in driving and maintaining rejection after transplantation.
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Background: Lifestyle interventions aiming to improve dietary habits, increase physical activity level, and improve emotional well-being can positively impact clinical outcomes in patients with chronic kidney disease (CKD). Educational material for health care professionals working with CKD patients that focuses on why and how to promote lifestyle changes is lacking. The present study aims to depict the material and dissemination methods for the peer-to-peer training program developed for health care professionals working in the dialysis clinics of the four countries engaged in the GoodRENal project: Spain, Greece, Sweden, and Belgium.

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