Publications by authors named "A H Schonthal"
Article Synopsis
- Spinal cord ischemia (SCI) poses significant risks during endovascular aortic aneurysm repair (EVAR), even though these procedures are less invasive than open surgery, necessitating strategies to maintain spinal cord blood flow.
- The study involved 16 EVAR cases across 15 patients, examining levels of oxidative stress and inflammatory markers before and after the procedures to understand their relationship to delayed SCI.
- Results showed a notable increase in the oxidative stress marker 8-OHdG at 48 hours post-procedure, highlighting its potential role in predicting SCI following EVAR.
Article Synopsis
- - The study focuses on a new device for intraventricular drug delivery that allows for wireless control of medication output, reducing toxicity while targeting the central nervous system directly.
- - Six sheep were implanted with a pump and catheter to administer varying doses of methotrexate (MTX) over 12 weeks, with drug levels monitored regularly.
- - Results showed no toxicity in sheep and confirmed that the device effectively maintained methotrexate levels in the cerebrospinal fluid through adjustable, metronomic delivery.
Article Synopsis
- eHsp90α is an extracellular protein that is released by cells in response to tissue injury, playing a key role in wound healing.
- Research shows that most of the eHsp90α in the extracellular environment exists in a trypsin-sensitive supernatant, suggesting it is primarily in a soluble form rather than in microvesicles or exosomes.
- The study identifies two gene families, AR and GRASP, that regulate the secretion of eHsp90α, highlighting their collaborative role in enhancing wound healing and providing a method to predict biomarkers from cell-conditioned medium data.
Background: The chemotherapeutic standard of care for patients with glioblastoma (GB) is radiation therapy (RT) combined with temozolomide (TMZ). However, during the twenty years since its introduction, this so-called Stupp protocol has revealed major drawbacks, because nearly half of all GBs harbor intrinsic treatment resistance mechanisms. Prime among these are the increased expression of the DNA repair protein O6-guanine-DNA methyltransferase (MGMT) and cellular deficiency in DNA mismatch repair (MMR).
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