Publications by authors named "A H Schnell"
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator therapy, inflammation and infection often persist. To elucidate the role of the innate immune system in CF etiology, we investigated a CF pig model and compared these results with those for preschool children with CF.
View Article and Find Full Text PDFT helper (Th) 17 cells encompass a spectrum of cell states, including cells that maintain homeostatic tissue functions and pro-inflammatory cells that can drive autoimmune tissue damage. Identifying regulators that determine Th17 cell states can identify ways to control tissue inflammation and restore homeostasis. Here, we found that interleukin (IL)-23, a cytokine critical for inducing pro-inflammatory Th17 cells, decreased transcription factor T cell factor 1 (TCF1) expression.
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- Humans and animals pursue both instrumental information for immediate decision-making and non-instrumental information that may be useful later, highlighting the complexity of curiosity.
- Recent studies suggest that curiosity, even when costly or unhelpful for immediate rewards, can be observed in nonhuman animals during tasks that involve uncertain outcomes.
- The text calls for further research on curiosity across various species to deepen our understanding of its cognitive mechanisms and evolutionary background, despite ongoing debates about the prevalence of curiosity in animals.*
Continuous flow magnetophoresis represents a common technique for actively separating particles within a fluid. For separation systems design, accurately predicting particle behaviour helps to characterise system performance, typically measured by the separation efficiency (SE). While finite element method (FEM) simulations offer high accuracy, they demand extensive computational resources.
View Article and Find Full Text PDFThe goal of this study was to investigate the relationship between mandibular distraction osteogenesis (MDO) and rates of postoperative gastrostomy tube (G-tube) placement among patients with isolated and syndromic Robin sequence (RS). This study was a multi-institutional retrospective chart review of patients with RS who underwent MDO at one of three different pediatric tertiary medical centers. The primary aim of the study was to compare rates of G-tube placement following MDO among the three institutions.
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