Publications by authors named "A H Pai"
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following loss of Pol II is not caused by dysregulated gene expression.
View Article and Find Full Text PDFBackground: Standard treatment for symptomatic chronic subdural hematoma (CSDH) is a burr-hole evacuation. However, in patients in whom surgical evacuation carries a very high risk, we do not have an established practice guideline.
Objective: To analyze the outcome of symptomatic CSDH treated only by tranexamic acid.
Validation of the Abbreviated PTSD Checklist-Civilian as a Traumatic Stress Screener for Parents of Children With Cancer.
J Pediatr Hematol Oncol Nurs
December 2024
Researchers and clinicians often use the six-item abbreviated Posttraumatic Stress Disorder Checklist-Civilian (PCL-6) for screening; however, the PCL-6 has not been validated for parents of children with cancer. A valid and reliable short screener like the PCL-6 would allow bedside and/or advanced practice nurses to quickly screen parents for traumatic stress and expedite referrals for support services. This study used data collected during a multisite trial examining an intervention for children with cancer and their parents.
View Article and Find Full Text PDFArticle Synopsis
- Understanding the roles of RNA and proteins is crucial for determining cell fate and designing effective gene circuits.
- The study utilizes HCR Flow-FISH to measure mRNA and protein levels in single cells, revealing that stronger synthetic promoters lead to higher RNA transcripts and translation rates.
- The research highlights the importance of polyadenylation signals and coding sequences, which can significantly affect mRNA and protein profiles, providing a new framework for comparing native and synthetic gene regulation.