Publications by authors named "A H Lundberg"
Background: This study updates the COVID-19 pandemic surveillance in East Asia and the Pacific we first conducted in 2020 with two additional years of data for the region.
Objective: First, we measure whether there was an expansion or contraction of the pandemic in East Asia and the Pacific region when the World Health Organization (WHO) declared the end of the COVID-19 public health emergency of international concern on May 5, 2023. Second, we use dynamic and genomic surveillance methods to describe the dynamic history of the pandemic in the region and situate the window of the WHO declaration within the broader history.
Tumors escape immune detection and elimination through a variety of mechanisms. Here, we used prostate cancer as a model to examine how androgen-dependent tumors undergo immune evasion through downregulation of the major histocompatibility complex class I (MHCI). We report that response to immunotherapy in late-stage prostate cancer is associated with elevated MHC expression.
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- Observational studies indicated that nontrauma centers were less likely to transfer insured injured patients to high-level trauma centers, leading to the investigation of insurance impact on transfer rates.
- The Affordable Care Act's dependent coverage provision, which allowed young adults to stay on their parents' insurance until 26, was utilized to explore changes in interhospital transfer rates.
- An analysis of data from the National Trauma Data Bank revealed no significant difference in transfer rates between younger and older patients before and after implementation of the dependent coverage provision, despite an increase in private insurance coverage among the younger cohort.
Article Synopsis
- - PARP inhibitors show promise in treating castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects, but the reasons behind resistance are not completely understood.
- - A study from the TOPARP-B trial found that 79% of BRCA2/PALB2-mutated tumors exhibited reversion mutations at the end of treatment, with many related to POLQ-mediated DNA repair mechanisms.
- - In cases of BRCA2 homozygous deletions, rare subclones lacking the BRCA2 deletion are selected for after PARP inhibitor treatment, indicating the necessity for restored HRR function in developing resistance.
Article Synopsis
- This study updates the COVID-19 pandemic situation in Canada using two additional years of data, focusing on the period leading up to the WHO's declaration of the end of the public health emergency on May 5, 2023.
- It summarizes the trends in COVID-19 transmissions and deaths, analyzes variant appearances using genomic data, and provides historical context for the pandemic's progression in Canada.
- The findings indicate that Canada's COVID-19 transmission rates remained below outbreak levels for eight months before the WHO announcement, while key persistence metrics showed a significant short-term positive trend but a negative long-term trend.