Publications by authors named "A H Jaffe"
Quantum error correction is believed to be essential for scalable quantum computation, but its implementation is challenging due to its considerable space-time overhead. Motivated by recent experiments demonstrating efficient manipulation of logical qubits using transversal gates [Bluvstein et al., Nature (London) 626, 58 (2024)NATUAS0028-083610.
View Article and Find Full Text PDFBackground: Underground research laboratories (URLs) provide a window on the deep biosphere and enable investigation of potential microbial impacts on nuclear waste, CO and H stored in the subsurface. We carried out the first multi-year study of groundwater microbiomes sampled from defined intervals between 140 and 400 m below the surface of the Horonobe and Mizunami URLs, Japan.
Results: We reconstructed draft genomes for > 90% of all organisms detected over a four year period.
Article Synopsis
- The medial frontal cortex (mFC) and locus coeruleus (LC) are brain regions linked to cognitive functions like attention, memory, and decision-making, yet their molecular regulators remain unclear.
- Using chemogenetic stimulation in mice, the study found that activating LC neurons targeting the mFC led to increased gene transcription, especially in GABAergic neurons related to cognitive functions.
- The research highlights the role of specific gene expression as potential biomarkers for neuropsychiatric disorders like ADHD, schizophrenia, and Alzheimer's, aiming to inform treatments for cognitive and behavioral symptoms.
Lipoprotein a (Lp(a)) is a lipid biomarker that binds cholesterol and bears independent cardiovascular risk. Strategies to lower the level of Lp(a) and mitigate such risk are important both for primary and secondary prevention. Currently there are no approved therapies targeting Lp(a) directly.
View Article and Find Full Text PDFObjective: To test the feasibility and safety of genotype guidance in the selection of P2Y monotherapy within 1 week of percutaneous coronary interventions (PCIs) among patients with high bleeding risk (HBR).
Patient And Methods: The study was a single-center, open-label, pilot trial. Patients (n=100) with HBR (as defined by an academic research consortium) after successful PCI received dual antiplatelet therapy with clopidogrel and aspirin.