Publications by authors named "A H Hsieh"
Background: Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among glioma patients who did and did not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to TMZ could personalize therapy and improve outcomes.
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- Gliomas are the most common malignant brain tumors, often leading to serious neurological issues and high mortality, yet they usually do not spread outside the brain, suggesting they depend on the brain's unique environment.* -
- This study used a special rabies virus tracing technique in a mouse model to identify neurons that connect with glioma cells, revealing various brain regions involved in glioma innervation.* -
- Molecular profiling showed that these connecting neurons (GINs) predominantly use glutamate and GABA neurotransmitters, and their electrophysiological properties differ from typical neurons, indicating a specific neural interaction that could influence glioma behavior.*
Overcoming resistance to therapy is a major challenge in castration-resistant prostate cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to adapt and survive targeted therapies. However, the molecular mechanisms of epigenetic reprogramming during this process are still poorly understood.
View Article and Find Full Text PDFPurpose Of Review: To review the evidence and describe the biological plausibility for the benefits of inhibiting cholesteryl ester transfer protein (CETP) on multiple organ systems through modification of lipoprotein metabolism.
Recent Findings: Results from observational studies, Mendelian randomization analyses, and randomized clinical trials support the potential of CETP inhibition to reduce atherosclerotic cardiovascular disease (ASCVD) risk through a reduction of apolipoprotein B-containing lipoproteins. In contrast, raising high-density lipoprotein (HDL) particles, as previously hypothesized, did not contribute to ASCVD risk reduction.