Port site hernia following transperitoneal laparoscopic pyeloplasty.

Most surgical procedures in the past were performed through large incisions. Advancement of laparoscopic surgery has led to smaller incisions and reduction in most of the incision-related complications. However, laparoscopic surgery has its own complications.

Impact of psychological wellbeing and academic readiness on early medical student attrition: educators' perspective.

Objectives: Medical school attrition is a complex problem, and improvement can only be achieved through the integrated involvement of all stakeholders. Mental health disorders are perceived to be prevalent among medical students in UAE. This study aimed to explore educators' perspectives on the high rate of early medical school attrition in UAE.

Streamlining management in thoracic trauma: radiomics- and AI-based assessment of patient risks.

Background: In blunt chest trauma, patient management is challenging because clinical guidelines miss tools for risk assessment. No clinical scale reliably measures the severity of cases and the chance of complications.

Aim: The objective of the study was to optimize the management of patients with blunt chest trauma by creating models prognosticating the transfer to the intensive care unit and in-hospital length of stay (LOS).

Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions.

Since 2020, many compounds have been investigated for their potential use in the treatment of SARS-CoV-2 infection. Among these agents, a huge number of natural products and FDA-approved drugs have been evaluated as potential therapeutics for SARS-CoV-2 using virtual screening and docking studies. However, the identification of the molecular targets involved in viral replication led to the development of rationally designed anti-SARS-CoV-2 agents.

Benzofuran and Benzo[b]thiophene-2-Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation.

A group of N-phenylbenzofuran-2-carboxamide and N-phenylbenzo[b]thiophene-2-carboxamide derivatives were designed and synthesized as a novel class of Aβ42 aggregation modulators. In the thioflavin-T based fluorescence aggregation kinetics study, compounds 4 a, 4 b, 5 a and 5 b possessing a methoxyphenol pharmacophore were able to demonstrate concentration dependent inhibition of Aβ42 aggregation with maximum inhibition of 54 % observed for compound 4 b. In contrast, incorporation of a 4-methoxyphenyl ring in compounds 4 d and 5 d led to a significant increase in Aβ42 fibrillogenesis demonstrating their ability to accelerate Aβ42 aggregation.