Publications by authors named "A H Goldstone"
Context: The liver/foregut satiety hormone liver-expressed antimicrobial peptide 2 (LEAP2) is an inverse agonist at the acyl ghrelin receptor (GHSR), increasing after food intake and decreasing after bariatric surgery and short-term nonsurgical weight loss, but effects of long-term dietary weight loss are unknown.
Objective: The objective of this study was to examine and compare the effects of these interventions on fasting and postprandial plasma LEAP2 and investigate potential metabolic mediators of changes in plasma LEAP2.
Methods: Plasma LEAP2 was measured in a previously published 2-year trial comparing standard medical management (SMM) (including 600-kcal/day deficit) with duodenal-jejunal bypass liner (DJBL, Endobarrier) insertion (explanted after 1 year) in adults with obesity and inadequately controlled type 2 diabetes mellitus.
Article Synopsis
- Surgeons often leave a residual atrial-level communication during Tetralogy of Fallot (TOF) repairs, and this study aimed to see how closing this communication affects patient recovery.
- The researchers reviewed records of 132 TOF patients who had surgery before 12 months old, comparing outcomes between those with and without the communication.
- The results showed no significant differences in key recovery metrics like cardiac output, drug therapy duration, or intensive care stay, suggesting that closing the communication doesn't significantly alter short-term or mid-term recovery outcomes.
Article Synopsis
- The Heart Valve Collaboratory is a collaborative group focused on innovative solutions for patients with heart valve disease, involving various stakeholders including healthcare professionals and industry partners.
- The Scientific Council includes cardiologists, surgeons, and representatives from regulatory bodies, who work together to identify and address patient needs.
- In October 2022, the group held a workshop to discuss the challenges and unmet needs in pediatric and congenital heart valve disease, resulting in a document summarizing their findings and current valve therapy landscape.*
Objective: Bicuspid aortic valve (AV) patients with aortic regurgitation (AR) differ from tricuspid AV patients given younger age, greater left ventricle (LV) compliance, and more prevalent aortic stenosis (AS). Bicuspid AV-specific data to guide timing of AV replacement or repair are lacking.
Methods: Adults with bicuspid AV and moderate or greater AR who underwent aortic valve replacement or repair at our center were studied.
Article Synopsis
- The study focuses on the long-term survival rates of adult patients with congenital heart disease who underwent orthotopic heart transplantation, distinguishing between those with single-ventricle versus biventricular circulation.
- A total of 61 patients were analyzed, with single-ventricle patients being younger and having more complications like cirrhosis and protein-losing enteropathy compared to biventricular patients.
- Five-year survival rates were significantly lower for single-ventricle patients (66%) than for biventricular patients (91%), indicating that the type of congenital heart disease affects post-transplant outcomes.