Behavioral and histopathologic effects following intrathecal administration of butorphanol, sufentanil, and nalbuphine in sheep.

A large number of opioids and nonopioids have been administered epidurally and intrathecally in the hope of providing segmental analgesia without serious adverse effects. However, neurotoxicity data are generally unavailable for many of these drugs. The present study evaluated the behavioral, motor, electroencephalographic, and histopathologic changes following intrathecal injection of large and small doses of butorphanol, sufentanil, and nalbuphine in sheep.

Osteomyelitis complicating fracture: pitfalls of 111In leukocyte scintigraphy.

111In-labeled leukocyte imaging has shown greater accuracy and specificity than alternative noninvasive methods in the detection of uncomplicated osteomyelitis. Forty patients with suspected osteomyelitis complicating fractures (with and without surgical intervention) were evaluated with 111In-labeled leukocytes. All five patients with intense focal uptake, but only one of 13 with no uptake, had active osteomyelitis.

Quantitative assessment of in vivo backscatter enhancement from gelatin microspheres.

Experimental work using a quantitative C-scan technique to measure in situ enhancement of hepatic backscatter resulting from the administration of gelatin microspheres to dogs is reported. We have found that reproducible enhancement of hepatic backscatter on the order of 2 dB followed the peripheral administration of gelatin within minutes, the magnitude of the effect was not sensitive to the rate of infusion, but was likely to be dose dependent, changes in the overlying tissue attenuation had a pronounced effect on the measurement, and the effect was sustained for up to one half hour or longer.

131I uptake in a benign serous cystadenoma of the ovary.

A patient with well-differentiated thyroid carcinoma had a whole body scan using 5 mCi 131I which demonstrated abnormal uptake of 131I in a palpable pelvic mass. Approximately 24 years ago the patient had a total thyroidectomy followed by 131I treatment. The histologic examination of the mass was consistent with serous cystadenoma of the ovary.