Publications by authors named "A H Emmett"
Article Synopsis
- Brain metastases significantly impact patients with metastatic melanoma, with a severe prognosis and limited durable responses to combined immune checkpoint inhibitors like PD-1 and CTLA-4, especially in symptomatic cases.
- Research shows that natural killer (NK) cells play a crucial role in enhancing the effectiveness of immune therapy against brain tumors, while their depletion leads to poorer outcomes and decreased CD8+ T cell levels within tumors.
- The study reveals that the effectiveness of PD-1/CTLA-4 blockade is dependent on chemokine-driven trafficking of CD8+ T cells to intracranial tumors, highlighting the complexity of immune responses in the brain.
Background: Optimizing access to high-quality scientific journals has become an important priority for academic departments, including the ability to read the scientific literature and the ability to afford to publish papers in those journals. In this contribution, we assess the question of whether institutional investment in scientific journals aligns with the journals where researchers send their papers for publication, and where they serve as unpaid reviewers and editors.
Methods: We assembled a unique suite of information about the publishing habits of our Department of Ecology and Evolutionary Biology, including summaries of 3,540 journal publications by 35 faculty members.
Chronic hepatitis C virus (HCV) infection has the greatest health impact in patients with advanced liver disease. The direct-acting antiviral (DAA) regimen glecaprevir/pibrentasvir (G/P) is approved for treatment of HCV-infected patients without cirrhosis and with compensated cirrhosis. However, events of liver decompensation/failure have been reported in patients treated with protease-inhibitor-containing DAA regimens, often in patients with advanced liver disease.
View Article and Find Full Text PDFObjectives: To identify and explore the experiences of health professionals towards using mobile electrocardiogram (ECG) technology.
Introduction: Mobile technology is increasingly being incorporated into healthcare systems, and when implemented well, has the potential to revolutionise the way in which care is delivered. The uptake of mobile ECG technology enables health professionals to record and transmit ECGs electronically, at the point of care.
Introduction: High efficacy and safety of 8-week glecaprevir/pibrentasvir (G/P) therapy was seen in hepatitis C (HCV)-infected, treatment-naïve (TN), compensated cirrhosis (CC) patients in EXPEDITION-8. To provide further understanding of the efficacy of G/P treatment in HCV-infected TN patients with CC and clinical evidence of portal hypertension (PHT), this analysis focused on differences in sustained virologic response at post-treatment week 12 (SVR12) between 8-week and 12-week G/P treatment groups in patients with PHT, and on differences in safety outcomes between PHT and non-PHT groups.
Methods: Data were derived from an ad hoc subgroup analysis of the EXPEDITION-8 study for patients receiving 8 weeks of G/P therapy, and pooled patient-level data from nine clinical studies for patients receiving 12 weeks of therapy.