Peroxisomal enzymes and 8-hydroxydeoxyguanosine in rat liver treated with perfluorooctanoic acid.

Although peroxisome proliferators are considered non-genotoxic agents, most of them, nevertheless, were found to promote and/or induce, hepatocellular carcinoma (HCC) in rodents. The aim of the present study is, first, to investigate whether the peroxisome proliferator perfluorooctanoic acid (PFOA) possesses inherent liver cancer promoting activity, and second, to study the possible mechanisms involved. To acheive these aims two protocols have been applied, a biphasic protocol (initiation by diethyl-nitrozamine (DEN) 200 mg/kg i.

Liver enzymes and protein electrophoretic patterns in hemodialysis patients with antibodies against the hepatitis C virus.

One hundred and forty nine patients with end-stage renal disease on regular hemodialysis were screened for antibodies against hepatitis C virus (HCV) and hepatitis B surface antigen (HBsAg). The overall prevalence of anti-HCV was 84.6%.