Publications by authors named "A H Creus"
Article Synopsis
- Necrotizing enterocolitis (NEC) significantly contributes to neonatal morbidity and mortality, and this study investigates whether congenital cardiopathy (CC) exacerbates the gastrointestinal and overall prognosis of NEC.
- The analysis included 190 neonates with NEC, comparing those with congenital cardiopathy to those without, revealing that CC patients had more frequent hemodynamic shock and longer hospital stays, along with higher mortality rates.
- Despite these differences in stability and outcomes, the need for surgery and intestinal involvement were similar between CC and non-CC patients.
Article Synopsis
- Chronic hepatitis B (CHB) poses a significant health challenge globally, and while there are limited treatment options, the oral drug JNJ-64794964 (JNJ-4964) is being tested for its potential effectiveness as a TLR7 agonist.
- In a phase 1 trial involving healthy volunteers, researchers analyzed blood samples to observe changes in gene expression and immune cell activity after administering JNJ-4964, finding notable increases in interferon-stimulated genes and activated natural killer (NK) and B cells.
- The results indicate that JNJ-4964 not only triggers a range of immune responses but also provides insights that could help develop biomarkers for monitoring CHB patients treated with TLR7 agonists
Background: Human metapneumovirus (HMPV) is an important aetiologic agent of respiratory tract infection (RTI). This study aimed to describe the prevalence, genetic diversity, and evolutionary dynamics of HMPV.
Methods: Laboratory-confirmed HMPV were characterised based on partial-coding G gene sequences with MEGA.
Background: JNJ-4964 is a TLR7 agonist, which, via a type I interferon (IFN)-dependent mechanism, may enhance host immunity suppressed by persistent exposure to hepatitis B antigens in chronic hepatitis B.
Methods: PK and PD data were pooled from 2 studies involving 90 participants ( = 74 JNJ-4964, dose range 0.2-1.