Publications by authors named "A H Combs"
OmpA controls order in the outer membrane and shares the mechanical load.
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- OmpA is an important outer membrane protein that influences bacterial virulence, adhesion, and membrane integrity, but its exact role has been unclear for over 50 years.
- This study reveals that OmpA plays a key role in organizing the outer membrane protein structure and connects it to the cell wall, helping to maintain the bacteria's protective barrier.
- The research shows that both parts of OmpA—its β-barrel domain and cell wall-binding domain—are essential for strengthening the bacterial envelope, making it more resilient and crucial for bacterial survival.
Periplasmic Chaperones: Outer Membrane Biogenesis and Envelope Stress.
Annu Rev Microbiol
November 2024
Article Synopsis
- Envelope biogenesis and homeostasis in gram-negative bacteria rely on a variety of specialized periplasmic chaperones that function without external energy sources like ATP.
- This article reviews key periplasmic chaperones that play crucial roles in forming the outer membrane and maintaining cellular envelope stability.
- Additionally, it addresses the stress responses related to unfolded proteins in the cell envelope, detailing how these chaperones help restore envelope homeostasis.