Pinaverium bromide.

The structure of pinaverium bromide (systematic name: 4-[(2-bromo-4,5-di-meth-oxy-phen-yl)meth-yl]-4-{2-[2-(6,6-dimethyl-2-bi-cyclo-[3.1.1]hepta-nyl)eth-oxy]eth-yl}morpholin-4-ium bromide; CHBrNO), was determined at 110 K.

Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy.

Purpose: Chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapies are effective in a subset of patients with solid tumors, but new approaches are needed to universally improve patient outcomes. Here, we developed a technology to leverage the cooperative effects of IL15 and IL21, two common cytokine-receptor gamma chain family members with distinct, pleiotropic effects on T cells and other lymphocytes, to enhance the efficacy of adoptive T cells.

Experimental Design: We designed vectors that induce the constitutive expression of either membrane-tethered IL15, IL21, or IL15/IL21.

Corrigendum: Individual, Sociodemographic, and Environmental Factors Related to Physical Activity During the Spring 2020 COVID-19 Lockdown.

[This corrects the article DOI: 10.3389/fpsyg.2021.

Crystal structures of two polymorphs of tixocortol pivalate.

Two polymorphs, () and (), of ()-{2-[(8,9,10,11,13,14,17)-11,17-dihy-droxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-deca-hydro-1-cyclo-penta-[]phenanthren-17-yl]-2-oxoeth-yl} 2,2-di-methyl-propane-thio-ate, CHOS, have been identified. They are ortho-rhom-bic, non-centrosymmetric (222). The structures display layers of mol-ecules conected O-H⋯O hydrogen bonds along the axis direction in polymorph () and along the axis direction in polymorph ().

Sustainable laser-based technology for insect pest control.

Aphids damage directly or indirectly cultures by feeding and spreading diseases, leading to huge economical losses. So far, only the use of pesticides can mitigate their impact, causing severe health and environmental issues. Hence, innovative eco-friendly and low-cost solutions must be promoted apart from chemical control.