Publications by authors named "A H Borman"
We describe 157 cases of Trichophyton indotineae infection in the United Kingdom, mostly in patients linked to southern Asia. T. indotineae is spreading in the United Kingdom and accounts for 38% of dermatophyte isolates referred to the UK National Mycology Reference Laboratory.
View Article and Find Full Text PDFMedically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal pathogens complete their life cycle in environmental habitats or occur as commensals within or on the vertebrate body, but under certain conditions can thrive upon infecting humans. The extent of host damage in opportunistic infections largely depends on the portal and modality of entry as well as on the host's immune and metabolic status.
View Article and Find Full Text PDFis a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates.
View Article and Find Full Text PDFArticle Synopsis
- Rezafungin is a newly approved drug for treating candidaemia and invasive candidiasis, marking a decade-long gap in new treatments, but research on its efficacy is limited.
- The study involved testing rezafungin and other echinocandins on various fungal isolates in infected mice, focusing on their effects on survival and fungal burdens in different organs.
- Results showed that rezafungin significantly reduced fungal loads in the kidney and heart, performed comparably or better than other echinocandins, but all treatments failed to effectively target fungal growth in the brain.
Article Synopsis
- Opportunistic fungal pathogens, like certain species, are gaining recognition in medical cases.
- A rare case of co-infection was observed in a 63-year-old heart transplant patient who had nodular skin lesions, successfully treated with voriconazole.
- The report emphasizes the need for awareness of co-infections with moulds to make better choices in antifungal treatments.