This work reports the performances of the magnetic chitosan@graphene oxide composite (MCh@GO) for the sorption of Nd(III) from aqueous medium. The prepared composite was synthesized by a coprecipitation method and then examined by FT-IR, XRD, SEM, and TGA. XRD analysis proved physical interactions between magnetic chitosan and graphene oxide through (inter- and intramolecular H-bonding and peptide bonding).
View Article and Find Full Text PDFWe provide promising computational (in silico) data on phytochemicals (compounds -) from Arabian Peninsula medicinal plants as strong binders, targeting 3-chymotrypsin-like protease (3CL) and papain-like proteases (PL) of SARS-CoV-2. Compounds - followed the Lipinski rules of five (RO5) and ADMET analysis, exhibiting drug-like characters. Non-covalent (reversible) docking of compounds - demonstrated their binding with the catalytic dyad (CYS145 and HIS41) of 3CL and catalytic triad (CYS111, HIS272, and ASP286) of PL.
View Article and Find Full Text PDFBackground: Targeting non-pulmonary vein triggers (NPVTs) after pulmonary vein isolation may reduce atrial fibrillation (AF) recurrence. Isoproterenol infusion and cardioversion of spontaneous or induced AF can provoke NPVTs but typically require vasopressor support and increased procedural time.
Objective: The purpose of this study was to identify risk factors for the presence of NPVTs and create a risk score to identify higher-risk subgroups.
COVID-19, a disease caused by SARS-CoV-2, has caused a huge loss of human life, and the number of deaths is still continuing. Despite the lack of repurposed drugs and vaccines, the search for potential small molecules to inhibit SARS-CoV-2 is in demand. Hence, we relied on the drug-like characters of ten phytochemicals (compounds -) that were previously isolated and purified by our research team from Saudi medicinal plants.
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