Antimicrobial susceptibility of Clostridium botulinum group III field strains isolated in Europe from animal outbreaks.

Neurotoxins produced by Clostridium (C.) botulinum group III are responsible for the majority of botulism outbreaks occurring in animals and in this study we report the drug susceptibility of 71 field strains. The minimum inhibitory concentration (MIC) of 13 antimicrobials was established through the agar dilution method.

Approximate likelihood and pseudo-likelihood inference in meta-analysis of diagnostic accuracy studies accounting for disease prevalence and study design.

Bivariate random-effects models represent a recommended approach for meta-analysis of diagnostic test accuracy, jointly modeling study-specific sensitivity and specificity. As the severity of the disease status can vary across studies, a proper analysis should account for the dependence of the accuracy measures on the disease prevalence. To this aim, trivariate generalized linear mixed-effects models have been proposed in the literature, although computational difficulties strongly limit their applicability.

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes.

Unlabelled: Following a diagnosis of type 1 diabetes (T1D), persisting C-peptide secretion leads to improved glycemic control and outcomes. Residual β-cell function is often assessed with serial mixed-meal tolerance tests, but these tests do not correlate well with clinical outcomes. Herein, we instead use β-cell glucose sensitivity (βGS) to assess changes in β-cell function, incorporating insulin secretion for a given serum glucose into the assessment of β-cell function.

A SIMEX approach for meta-analysis of diagnostic accuracy studies with attention to ROC curves.

Bivariate random-effects models represent an established approach for meta-analysis of accuracy measures of a diagnostic test, which are typically given by sensitivity and specificity. A recent formulation of the classical model describes the test accuracy in terms of study-specific Receiver Operating Characteristics curves. In this way, the resulting summary curve can be thought of as an average of the study-specific Receiver Operating Characteristics curves.

Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis.

Context: Loss of the incretin effect (IE) in type 2 diabetes (T2D) contributes to hyperglycemia and the mechanisms underlying this impairment are unclear.

Objective: To quantify the IE impairment in T2D and to investigate the factors associated with it using a meta-analytic approach.

Methods: PubMed, Scopus, and Web-of-Science were searched.