Publications by authors named "A Guillen-Del-Castillo"
Background: Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by microvascular damage and fibrosis. Mortality in patients with SSc has significantly decreased. Consequently, patients with SSc have longer life expectancy, and health-related quality of life (HrQoL) has become more relevant in the comprehensive management of the disease.
View Article and Find Full Text PDFExpanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing.
Janire Perurena-Prieto María Teresa Sanz-Martínez Laura Viñas-Giménez Claudia Codina-Clavaguera Laura Triginer Alfredo Guillen-Del-Castillo
J Autoimmun
December 2024
Article Synopsis
- The study focused on creating a new test to detect specific autoantibodies in patients with systemic sclerosis (SSc) using RNA immunoprecipitation and massive parallel sequencing techniques.
- Researchers analyzed serum samples from 307 SSc patients, with 57 undergoing detailed testing that identified 30,966 RNA molecules, ultimately narrowing down to 197 significant molecules linked to SSc-related autoantibodies.
- The new assay demonstrated high sensitivity and specificity in detecting autoantibodies, revealing not only known targets but also potential new ones associated with different clinical aspects of SSc.
Article Synopsis
- The study aimed to assess microcirculation abnormalities in patients with Behçet's Syndrome (BS) and their link to vascular issues using nailfold videocapillaroscopy (NVC).
- Out of 65 patients, 36.9% showed vascular involvement, with NVC revealing abnormalities like tortuous capillaries and microhaemorrhages in nearly half of the participants.
- Significant correlations were found between specific NVC abnormalities and vascular complications, indicating that NVC could be useful for early identification of patients at risk for vascular events.
Article Synopsis
- * A study involving 69 patients found that a significant number (33%) had PPI-refractory esophagitis, which was notably more common among those with diffuse systemic sclerosis.
- * Gastrointestinal dysmotility, linked to abnormal digestion processes, was independently associated with PPI-refractory esophagitis, while factors like absent esophageal contractility were not significant.