Publications by authors named "A Guerrero Espejo"
Surgical removal of primary tumors was shown to reverse tumor-mediated immune suppression in pre-clinical models with metastatic disease. However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, especially in the context of immune checkpoint therapy (ICT)-containing treatments is not understood. Here, we report the first prospective, non-comparative clinical trial to evaluate the feasibility, clinical benefits, and immunologic changes of combining three different ICT-containing strategies with cytoreductive surgery or biopsy for patients with metastatic clear cell renal cell carcinoma (mccRCC).
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- - The study evaluates the effectiveness and safety of adalimumab in treating non-infectious uveitis across four Spanish hospitals from 2012 to 2022, analyzing patient data on relapses, inflammation, and medication dosage changes.
- - Out of 122 patients, most were middle-aged Caucasian women with refractory uveitis; results showed significant reductions in both relapses and corticosteroid use, along with improved visual acuity.
- - Overall, adalimumab demonstrated high efficacy and safety in managing non-infectious uveitis, with minimal serious side effects and a low incidence of anti-drug antibody development.
Article Synopsis
- Glioblastoma (GBM) is a challenging brain cancer with poor outcomes, and understanding its tumor microenvironment could improve treatment effectiveness.
- The study adapts stereotactic biopsies to gather multi-omics data from GBM patients, revealing detailed insights into the tumor and immune response.
- Results indicate that stereotactic needle biopsies can provide high-quality samples for comprehensive analysis, aiding in monitoring treatment responses and furthering research.
Antecedentes: El síndrome de Wiskott-Aldrich (SWA) es un raro trastorno ligado al cromosoma X que se considera que afecta predominantemente a varones.
Objetivo: El objetivo de este estudio consistía en investigar la incidencia y la mortalidad intrahospitalaria del SWA en España, así como el sesgo de género.
MÉtodos: Se llevó a cabo un estudio epidemiológico retrospectivo poblacional en 97 pacientes con SWA diagnosticados en hospitales españoles entre 1997 y 2017, utilizando para ello datos del Sistema Nacional de Vigilancia de Datos Hospitalarios.
This work analyzes the magnetic configurations of cylindrical nanowires with a bulk Dzyaloshinskii-Moriya interaction and easy-plane anisotropy. We show that this system allows the nucleation of a metastable toron chain even when no out-of-plane anisotropy exists in the nanowire's top and bottom surfaces, as usually required. The number of nucleated torons depends on the nanowire length and the strength of an external magnetic field applied to the system.
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