Publications by authors named "A Gueguen"
Article Synopsis
- Intravascular lymphoma is a rare B-cell lymphoma that primarily affects small blood vessels and often involves the central nervous system (CNS), making early diagnosis challenging due to non-specific symptoms.
- A study analyzed data from 17 patients, finding that most experienced sudden neurological episodes, rapid cognitive decline, and unique MRI characteristics, alongside other clinical signs such as elevated LDH levels.
- The research identified key features, or "red flags," that could aid in quicker diagnosis of CNS-involving intravascular lymphoma, emphasizing the importance of recognizing these indicators.
Head and neck squamous cell carcinoma (HNSCC) remains a malignancy with high rates of locoregional recurrence and poor prognosis for recurrent cases. Early detection of subclinical lesions is challenging but critical for effective patient management. Imaging surveillance after treatment, particularly F-FDG PET/CT, has shown promise in the diagnosis of HNSCC recurrence.
View Article and Find Full Text PDFBackground: Natalizumab is a high-efficacy therapy for recurrent multiple sclerosis (RMS) with a four-week administration interval. Controlled trials have shown that extending this interval to six weeks led to better safety without increasing the risk of relapse. We aimed to analyze the safety of extending the natalizumab interdose interval from 4 to 6 weeks in a real-life setting.
View Article and Find Full Text PDFThe immune system plays a significant role in multiple sclerosis. While MS was historically thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells are essential players in multiple sclerosis pathogenic processes. High-efficacy disease-modifying therapies that target the immune system have emerged over the past two decades.
View Article and Find Full Text PDFBackground: Using reliable contrast-enhanced T1 sequences is crucial to detect enhancing brain lesions for multiple sclerosis (MS) at the time of diagnosis and over follow-up. Contrast-enhanced 3D gradient-recalled echo (GRE) T1-weighted imaging (WI) and 3D turbo spin echo (TSE) T1-WI are both available for clinical practice and have never been compared within the context of this diagnosis.
Purpose: The aim of this study was to compare contrast-enhanced 3D GRE T1-WI and 3D TSE T1-WI for the detection of enhancing lesions in the brains of MS patients.