Publications by authors named "A Guarina"
Metachronous Bilateral Adrenal Neuroblastoma: A Case Report and Literature Review.
J Pediatr Hematol Oncol
November 2024
A baby presented with a large right adrenal mass, multiple hepatic lesions and diffuse bone marrow infiltration when she was just over 1 month old. After needle biopsy and a histologic definition of neuroblastoma, she underwent chemotherapy and a subsequent complete resection. Three years after diagnosis, a large left adrenal localized mass was detected.
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- - Acquired aplastic anemia (AA) is a rare condition involving low blood cell counts and underdeveloped bone marrow, affecting 2-3 people per million in Western countries and more in East Asia.
- - Treatments for severe aplastic anemia (SAA) have improved significantly, with hematopoietic stem cell transplantation (HSCT) from a matched sibling donor considered the best first-line approach, although alternatives exist if a sibling donor isn't available.
- - A guideline developed by pediatric hematologists aims to assist healthcare professionals in diagnosing and managing AA in children, based on evidence gathered and discussions held during consensus conferences, including adaptations made due to the COVID-19 pandemic.
Fanconi anemia (FA) is a genome instability condition that drives somatic mosaicism in up to 25% of all patients, a phenomenon now acknowledged as a good prognostic factor. Herein, we describe the case of P1, a FA proband carrying a splicing variant, molecularly compensated by a insertion. Targeted next-generation sequencing on P1's peripheral blood DNA detected the known c.
View Article and Find Full Text PDFBackground: Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes.
Case Presentation: We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally.
Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain. The aim of this study was to characterize the coexistence of these two diseases in Italian children.
Materials And Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019.