Publications by authors named "A Gruden-Movsesijan"
Over-activated myeloid cells and disturbance in gut microbiota composition are critical factors contributing to the pathogenesis of Multiple Sclerosis (MS). Myeloid-derived suppressor cells (MDSCs) emerged as promising regulators of chronic inflammatory diseases, including autoimmune diseases. However, it remained unclear whether MDSCs display any therapeutic potential in MS, and how this therapy modulates gut microbiota composition.
View Article and Find Full Text PDFArticle Synopsis
- Muscle larvae excretory-secretory products (ES L1) have been shown to influence immune responses, particularly in dendritic cells, and may help manage autoimmune diseases by promoting tolerogenic DCs that support immune balance.
- This research focused on isolating and characterizing proteins from ES L1 that demonstrate galectin-1-like properties, specifically the ability to recognize lactose, and identified a protein (TsGal-1-like) that can induce regulatory T cell responses.
- Despite identifying nineteen proteins, none matched known galectin family members; however, the isolated proteins showed galectin-1-like traits, indicating the potential for further research into their structure and immune regulatory roles.
Trichinellosis in humans is most often caused by the parasite Trichinella spiralis. The clinical course of the disease is diverse and the symptoms can vary from mild to severe. Symptoms usually disappear within a few months, but encysted larvae in the muscles can cause myalgia and weakness that last for years.
View Article and Find Full Text PDFAn outbreak of trichinellosis occurred in Stari Banovci, a settlement in the municipality of Stara Pazova, Srem, Republic of Serbia, in March-April 2019. A total of 28 persons were exposed and trichinellosis was confirmed in 24 of them. This outbreak involved members of eight families, their relatives and friends.
View Article and Find Full Text PDFArticle Synopsis
- The rise in autoimmune diseases in developed countries is linked to better living conditions and reduced exposure to beneficial infectious agents like helminths, which play a role in immune regulation.
- Research indicates that Trichinella spiralis, a type of helminth, can lessen harmful immune responses and promote protective T cell responses by influencing dendritic cells.
- Recent advances in nanotechnology allow for the delivery of multiple signals in tiny packages, suggesting that combining treatments could be an effective strategy for addressing autoimmune diseases, despite challenges in replicating natural systems.